Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen‐Synthease‐Kinase‐3‐Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo

@inproceedings{Clough2018RapidOE,
  title={Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen‐Synthease‐Kinase‐3‐Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo},
  author={Bret H. Clough and Suzanne Zeitouni and Ulf Krause and Christopher D. Chaput and Lauren M Cross and Akhilesh K Gaharwar and Carl A Gregory},
  booktitle={Stem cells translational medicine},
  year={2018}
}
Non-union defects of bone are a major problem in orthopedics, especially for patients with a low healing capacity. Fixation devices and osteoconductive materials are used to provide a stable environment for osteogenesis and an osteogenic component such as autologous human bone marrow (hBM) is then used, but robust bone formation is contingent on the healing… CONTINUE READING