Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions

  title={Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions},
  author={Zinia Jaman and Tiago Jose Paschoal Sobreira and Ahmed Mufti and Christina Ramires Ferreira and R. Graham Cooks and David H. Thompson},
  journal={Organic Process Research \& Development},
Lomustine, an important agent for treatment of brain tumors and Hodgkin’s lymphoma, has been synthesized using continuous flow methodology. Desorption electrospray ionization mass spectrometry (DESI-MS) was used to quickly explore a large number of reaction conditions for one of the reaction steps and guide the efficient translation of optimized conditions to continuous lomustine production. Using only four inexpensive commercially available starting materials and a total residence time of 9… 

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