Rapid Non-Genomic Feedback Effects of Glucocorticoids on CRF-Induced ACTH Secretion in Rats

@article{Hinz2004RapidNF,
  title={Rapid Non-Genomic Feedback Effects of Glucocorticoids on CRF-Induced ACTH Secretion in Rats},
  author={B. Hinz and R. Hirschelmann},
  journal={Pharmaceutical Research},
  year={2004},
  volume={17},
  pages={1273-1277}
}
AbstractPurpose. The present study investigates fast negative feedback actions of corticosterone (corticosteroid type I/type II receptor agonist) and RU 28362 (corticosteroid type II receptor agonist) on corticotropin-releasing factor (CRF)-induced adrenocorticotropic hormone (ACTH) secretion in rats. Methods. To induce fast feedback, glucocorticoids were administered intravenously immediately before injection of the hypophyseotropic stimulus CRF. Plasma ACTH levels, being determined 5 to 30… Expand
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