Rapid Modulation of-Opioid Receptor Signaling in Primary Sensory Neurons

@inproceedings{Berg2007RapidMO,
  title={Rapid Modulation of-Opioid Receptor Signaling in Primary Sensory Neurons},
  author={Kelly A. Berg and Amol M. Patwardhan and Teresa A. Sanchez and Yamille M. Silva and Kenneth M Hargreaves and William P Clarke},
  year={2007}
}
Management of pain by opioid analgesics is confounded by central adverse effects that limit clinical dosages. Consequently, there is considerable interest to understand peripheral analgesic effects of opioids. The actions of opioids on peripheral sensory neurons have been difficult to study because of a general lack of effect of opioid agonists on nociceptor function in culture despite documented presence of opioid receptors. In this study, the -opioid receptor agonist, [D-Ala,N-MePhe,Gly-ol… CONTINUE READING
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