Rapid LC-MS/MS determination and pharmacokinetic application of linarin in rat plasma.

@article{Yan2013RapidLD,
  title={Rapid LC-MS/MS determination and pharmacokinetic application of linarin in rat plasma.},
  author={Chong Yan and Hongju Liu and Li Lin},
  journal={Biomedical chromatography : BMC},
  year={2013},
  volume={27 2},
  pages={186-90}
}
A sensitive, selective and robust liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the rapid determination of linarin in rat plasma. Separation of the analyte and warfarin as internal standard (IS) from 100 μL rat plasma was carried out by simple protein precipitation treatment. Chromatographic separation of the analyte was performed on a Diamonsil® C(18) column (150 × 4.6 mm, 5 µm) using isocratic mobile phase consisting of methanol-0.5% formic acid (80:20, v… CONTINUE READING