Rapid Intraoperative Immunohistochemical Evaluation of Sentinel Lymph Nodes for Metastatic Breast Carcinoma

@article{Johnston2006RapidII,
  title={Rapid Intraoperative Immunohistochemical Evaluation of Sentinel Lymph Nodes for Metastatic Breast Carcinoma},
  author={Elizabeth I Johnston and Robyn A Beach and Sandra M. Waldrop and Diane Lawson and Cynthia Cohen},
  journal={Applied Immunohistochemistry \& Molecular Morphology},
  year={2006},
  volume={14},
  pages={57-62}
}
ObjectiveSentinel lymph node (SLN) biopsy is an integral part of the surgical management of patients with breast cancer. Rapid immunohistochemistry (RIHC) has the potential to increase detection of metastatic carcinoma at the time of frozen section consultation. The authors assessed the accuracy and turnaround time of a newly developed RIHC method for pancytokeratin (RIHC-CK). MethodsSixty-six SLNs from 32 patients with breast carcinoma were examined for metastasis using the Zymed Sentinel… Expand
Precise Pathologic Examination Decreases the False-Negative Rate of Sentinel Lymph Node Biopsy in Gastric Cancer
TLDR
This study indicated that precise and detailed intraoperative examination decreases the false-negative rate of SLN biopsy, andITCs in SLNs should not be overlooked, and rapid IHC can be helpful for detecting ITCs intraoperatively. Expand
Cytokeratin on Frozen Sections of Sentinel Node May Spare Breast Cancer Patients Secondary Axillary Surgery
TLDR
IHC on frozen section leads to the detection of more ITC and MIC intraoperatively, which can lead to fewer secondary ALNDs and improve the specificity and positive predictive value of SN evaluation. Expand
Precise Pathologic Examination Decreases the False-Negative Rate of Sentinel Lymph Node Biopsy in Gastric Cancer
Gastric cancer has been identified as a target for sentinel lymph node (SLN) navigational surgery. Although accurate evaluation of SLNs is essential for applying the SLN concept to gastric cancerExpand
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TLDR
In conclusion, intraoperative IHC staining of the SNB lowered the late positive rate and gave an overall cost saving. Expand
Imprint cytology versus frozen section analysis for intraoperative assessment of sentinel lymph node in breast cancer
TLDR
Initial lesion size and lymphovascular invasion play a pivotal role in metastatic involvement of the SLN with the dimensions of metastasis bearing no correlation with tumor size. Expand
Efficacy of intraoperative GeneSearch Breast Lymph Node (BLN) Assay for breast cancer metastasis detection in sentinel lymph node in Chinese patients
TLDR
The results from a large series of Chinese patients with breast cancer indicate that the BLN assay may be a viable alternative for the standard intraoperative procedures used for metastases detection, especially in early stage breast cancer patients. Expand
Comparison of Diagnostic Accuracy of Frozen Section with Imprint Cytology for Intraoperative Examination of Sentinel Lymph Node in Early-Stage Endometrial Cancer: Results of Senti-Endo Study
TLDR
FS has better DA than IC for intraoperative examination of SLNs in endometrial cancer, and the main limitation of both techniques is in detecting micrometastasis and isolated tumor cells. Expand
False-Negative Interpretation of Breast Sentinel Lymph Node Touch Preps: Analysis of the Causes with Suggestions to Improve Diagnostic Accuracy
TLDR
TPs with scant cellularity, unsatisfactory TP’s and failure to identify tumor cells with low nuclear grade were found to significantly contribute to false-negative interpretations and it is suggested that an additional TP or frozen section may be necessary if the cellularity of the initial TP is limited. Expand
Preoperative Identification of the Sentinel Lymph Node in Breast Cancer
TLDR
Preoperative identification, core needle biopsy, and documentation of metastasis in the first SLN in breast cancer was achieved by focused lower ipsilateral axillary US. Expand
Management of the axilla in patients with breast cancer
  • A. Goyal
  • Medicine
  • The Indian journal of surgery
  • 2009
TLDR
The changes in management of the axilla in patients with breast cancer in the last decade are reviewed and predictive models can be used to identify a lowrisk group of SLN-positive patients in whom routine ALND may not be necessary. Expand
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