Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys

@article{Barouch2016RapidIA,
  title={Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys},
  author={Dan Barouch and Khader Ghneim and William J Bosche and Yuan Li and Brian Berkemeier and Michael Hull and Sanghamitra Bhattacharyya and Mark Cameron and Jianhua Liu and Kaitlin Smith and Erica N. Borducchi and Crystal Cabral and Lauren E. Peter and Amanda L. Brinkman and Mayuri Shetty and Hualin Li and Courtney Gittens and Chantelle Baker and Wendeline Wagner and Mark G Lewis and Arnaud D. Colantonio and Hyung-Joo Kang and Wenjun Li and Jeffrey D Lifson and Michael Piatak and Rafick-Pierre S{\'e}kaly},
  journal={Cell},
  year={2016},
  volume={165},
  pages={656-667}
}
The earliest events following mucosal HIV-1 infection, prior to measurable viremia, remain poorly understood. Here, by detailed necropsy studies, we show that the virus can rapidly disseminate following mucosal SIV infection of rhesus monkeys and trigger components of the inflammasome, both at the site of inoculation and at early sites of distal virus spread. By 24 hr following inoculation, a proinflammatory signature that lacked antiviral restriction factors was observed in viral RNA-positive… CONTINUE READING

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