Rapid Induction of Mammary Carcinoma in the Rat and the Influence of Hormones on the Tumors

@article{Huggins1959RapidIO,
  title={Rapid Induction of Mammary Carcinoma in the Rat and the Influence of Hormones on the Tumors},
  author={Charles Huggins and Giuliano Briziarelli and Harold Sutton},
  journal={The Journal of Experimental Medicine},
  year={1959},
  volume={109},
  pages={25 - 42}
}
A study was made of the optimal conditions for the induction of mammary cancer in the rat. 3-Methylcholanthrene was administered via the gastrointestinal tract, and a simple technique was worked out for inducing mammary cancer regularly and rapidly. Under conducive conditions, which were readily reproduced, multiple mammary carcinomas and these tumors only were induced in every rat in repeated experiments in 60 days or less. In the strain of animal employed in the present experiments, the rapid… CONTINUE READING

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