Rapid Induction of Mammary Carcinoma in the Rat and the Influence of Hormones on the Tumors

  title={Rapid Induction of Mammary Carcinoma in the Rat and the Influence of Hormones on the Tumors},
  author={Charles Huggins and Giuliano Briziarelli and Harold Sutton},
  journal={The Journal of Experimental Medicine},
  pages={25 - 42}
A study was made of the optimal conditions for the induction of mammary cancer in the rat. 3-Methylcholanthrene was administered via the gastrointestinal tract, and a simple technique was worked out for inducing mammary cancer regularly and rapidly. Under conducive conditions, which were readily reproduced, multiple mammary carcinomas and these tumors only were induced in every rat in repeated experiments in 60 days or less. In the strain of animal employed in the present experiments, the rapid… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 110 extracted citations

Role of the Transcriptome in Breast Cancer Prevention

Springer US • 2013
View 5 Excerpts
Highly Influenced

Pregnancy-Induced Changes in Breast Cancer Risk

Journal of Mammary Gland Biology and Neoplasia • 2011
View 5 Excerpts
Highly Influenced

Endocrine Therapies in Breast and Prostate Cancer

Cancer Treatment and Research • 1988
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 25 references

The carcinogenic action of 2-acetylaminofluorene and related compounds.

British medical bulletin • 1946
View 5 Excerpts
Highly Influenced

Effects of 3-methylcholanthrene on the endocrine system and metabolism of the rat and its influence to retard growth of mammary tumors hitherto refractory

C. Huggins, L. PoUice
J. Exp. Med., • 1958
View 1 Excerpt

Preliminary studies with mammary tumors in the rat induced by 7,12-dimethylbenz(a)anthracene (DMBA)

J. Scholler, R. E. Carnes
Proc. Am. Assn. Cancer Research, • 1958
View 3 Excerpts

Microscopic Histochemistry, Principles and Practice, Chicago, The University of Chicago Press, 1952

G. Gomori
View 2 Excerpts

Similar Papers

Loading similar papers…