Rapid Identification of a Protein Binding Partner for the Marine Natural Product Kahalalide F by Using Reverse Chemical Proteomics

@article{Piggott2008RapidIO,
  title={Rapid Identification of a Protein Binding Partner for the Marine Natural Product Kahalalide F by Using Reverse Chemical Proteomics},
  author={Andrew M. Piggott and P. Karuso},
  journal={ChemBioChem},
  year={2008},
  volume={9}
}
Kahalalide F (KF) is in phase II clinical trials as an anticancer drug against a range of difficult to treat solid tumors including prostate, breast and colon carcinomas, neuroblastomas, chondrosarcomas, and osteosarcomas and has relatively low toxicity to nontumor cells. KF was originally isolated by Hamann and Scheuer from the sacoglossan marine mollusk, Elysia rufescens, and subsequently from the sacoglossan’s food source, the green alga Bryopsis sp. In phase I clinical trials, KF had a… Expand
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