Rapid HPLC-MS/MS method for simultaneous quantitation of four routinely administered triazole antifungals in human plasma.

@article{Beste2012RapidHM,
  title={Rapid HPLC-MS/MS method for simultaneous quantitation of four routinely administered triazole antifungals in human plasma.},
  author={Kerstin Yvonne Beste and Olaf Burkhardt and Volkhard Kaever},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2012},
  volume={413 1-2},
  pages={240-5}
}
BACKGROUND Fluconazole, itraconazole, posaconazole and voriconazole are four triazole antifungal drugs administered for the prevention and in the treatment of invasive fungal infections. Therapeutic drug monitoring of these antifungals in human plasma is advised. METHODS After protein precipitation by adding methanol/ZnSO(4) containing ketoconazole as… CONTINUE READING