Rapid GLC determination of fusaric acid in biological fluids.

  title={Rapid GLC determination of fusaric acid in biological fluids.},
  author={K. Fung and R. Koda and R. Maronde and J. Cohen},
  journal={Journal of pharmaceutical sciences},
  volume={65 4},
A simple, sensitive GLC assay was developed for fusaric acid, the active metabolite of bupicomide, to follow the disposition of this investigational antihypertensive agent in patients undergoing therapy. Fusaric acid is efficiently extracted from biological samples, derivatized by on-column methylation, and chromatographed using flame-ionization detection. An internal standard is utilized to quantitate results. The procedure is rapid and specific for fusaric acid, and has a lower limit of… Expand
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