Rapid Formation of Cell Aggregates and Spheroids Induced by a "Smart" Boronic Acid Copolymer.

@article{Amaral2016RapidFO,
  title={Rapid Formation of Cell Aggregates and Spheroids Induced by a "Smart" Boronic Acid Copolymer.},
  author={Ad{\'e}rito J. R. Amaral and George Pasparakis},
  journal={ACS applied materials & interfaces},
  year={2016},
  volume={8 35},
  pages={
          22930-41
        }
}
Cell surface engineering has emerged as a powerful approach to forming cell aggregates/spheroids and cell-biomaterial ensembles with significant uses in tissue engineering and cell therapeutics. Herein, we demonstrate that cell membrane remodeling with a thermoresponsive boronic acid copolymer induces the rapid formation of spheroids using either cancer or cardiac cell lines under conventional cell culture conditions at minute concentrations. It is shown that the formation of well-defined… CONTINUE READING
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