Rapid Effects of Deep Brain Stimulation for Treatment-Resistant Major Depression

@article{Schlaepfer2013RapidEO,
  title={Rapid Effects of Deep Brain Stimulation for Treatment-Resistant Major Depression},
  author={Thomas E. Schlaepfer and Bettina H. Bewernick and Sarah Kayser and Burkhard M{\"a}dler and Volker Arnd Coenen},
  journal={Biological Psychiatry},
  year={2013},
  volume={73},
  pages={1204-1212}
}
BACKGROUND Treatment-resistant major depressive disorder is a prevalent and debilitating condition. Deep brain stimulation to different targets has been proposed as a putative treatment. METHODS In this pilot study, we assessed safety and efficacy of deep brain stimulation to the supero-lateral branch of the medial forebrain bundle in seven patients with highly refractory depression. Primary outcome criterion was severity of treatment-resistant major depressive disorder as assessed with the… Expand

Paper Mentions

Interventional Clinical Trial
This research study will investigate the safety, tolerability, and benefit of bilateral deep brain stimulation (DBS) to the lateral habenula in subjects with treatment-resistant major… Expand
ConditionsTreatment Resistant Major Depressive Disorder
InterventionDevice, Other
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References

SHOWING 1-10 OF 64 REFERENCES
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
TLDR
Preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. Expand
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
TLDR
Deep brain stimulation of the VC/VS offers promise for the treatment of refractory major depression. Expand
Long-Term Effects of Nucleus Accumbens Deep Brain Stimulation in Treatment-Resistant Depression: Evidence for Sustained Efficacy
TLDR
First-time, preliminary long-term data on NAcc-DBS have demonstrated a stable antidepressant and anxiolytic effect and an amelioration of QoL in this small sample of patients suffering from treatment-resistant depression. Expand
Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression
BACKGROUND While most patients with depression respond to combinations of pharmacotherapy, psychotherapy, and electroconvulsive therapy (ECT), there are patients requiring other treatments. DeepExpand
Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression
TLDR
This study suggests that DBS is relatively safe and provides significant improvement in patients with TRD and likely acts by modulating brain networks whose dysfunction leads to depression. Expand
Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression: Effects of 12-month stimulation
  • C. Grubert, R. Hurlemann, +5 authors T. Schlaepfer
  • Psychology, Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2011
TLDR
The results not only support cognitive safety of NAcc-DBS but also stress its beneficial role in augmenting cognitive performance in patients with TRD. Expand
Antidepressant effects of ketamine in depressed patients
TLDR
A first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression suggests a potential role for NMDA receptor-modulating drugs in the treatment of depression. Expand
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
TLDR
Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week. Expand
The definition and meaning of treatment-resistant depression.
  • H. Sackeim
  • Medicine
  • The Journal of clinical psychiatry
  • 2001
TLDR
The Antidepressant Treatment History Form is presented as one method to formalize the evaluation of treatment adequacy and treatment resistance. Expand
Major depressive disorder: new clinical, neurobiological, and treatment perspectives
TLDR
This Seminar discusses developments from the past 5 years in the diagnosis, neurobiology, and treatment of major depressive disorder and addresses two treatment-related issues: suicide risk with selective serotonin reuptake inhibitors and the safety of antidepressants in pregnancy. Expand
...
1
2
3
4
5
...