Rapid Effector Function in CD8+ Memory T Cells

  title={Rapid Effector Function in CD8+ Memory T Cells },
  author={Ajit Lalvani and Roger Brookes and Sophie Hambleton and Warwick John Britton and Adrian V S Hill and Andrew J McMichael},
  journal={The Journal of Experimental Medicine},
  pages={859 - 865}
The nature of the CD8+ T cells that underlie antiviral protective immunological memory in vivo is unclear. We have characterized peptide-specific CD8+ T lymphocytes directly ex vivo from peripheral blood in humans with past exposure to influenza virus, using single cell interferon gamma (IFN-gamma) release as a measure of effector function. In individuals in the memory state with respect to influenza virus infection, unrestimulated antigen-specific CD8+ T cells displayed IFN-gamma release… CONTINUE READING


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