Rapid Diagnostic Tests for Group A Streptococcal Pharyngitis: A Meta-analysis

@article{Lean2014RapidDT,
  title={Rapid Diagnostic Tests for Group A Streptococcal Pharyngitis: A Meta-analysis},
  author={Wei Ling Lean and Sarah J. Arnup and Margie Danchin and Andrew C. Steer},
  journal={Pediatrics},
  year={2014},
  volume={134},
  pages={771 - 781}
}
BACKGROUND AND OBJECTIVE: Effective management of group A streptococcal (GAS) pharyngitis is hindered by impracticality of the gold standard diagnostic test: throat culture. Rapid antigen diagnostic tests (RADTs) are a promising alternative, although concerns about their sensitivity and specificity, and variation between test methodologies, have limited their clinical use. The objective of this study was to perform a systematic review with meta-analysis of the diagnostic accuracy of RADTs for… Expand
Rapid Diagnostic Tests for Group A Streptococcal Pharyngitis: A Meta-analysis abstract
BACKGROUND AND OBJECTIVE: Effective management of group A streptococcal (GAS) pharyngitis is hindered by impracticality of the gold standard diagnostic test: throat culture. Rapid antigen diagnosticExpand
Sensitivity for Diagnosing Group A Streptococcal Pharyngitis from Manufacturers is 10% Higher than Reported in Peer-Reviewed Publications
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Packaging inserts include sponsored studies that overestimate the sensitivity of rapid tests to diagnose GAS pharyngitis by approximately 10%. Expand
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The high diagnostic accuracy of RNATs may allow their use as stand-alone tests to diagnose GAS pharyngitis and should be evaluated in point-of-care settings. Expand
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TLDR
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Diagnosis and antibiotic treatment of group a streptococcal pharyngitis in children in a primary care setting: impact of point-of-care polymerase chain reaction
TLDR
Under real-world conditions, RADT results wereLess specific and culture results were less sensitive than found in established literature and led to increased rates of inappropriate antibiotic use. Expand
Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review
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Potential for Molecular Testing for Group A Streptococcus to Improve Diagnosis and Management in a High-Risk Population: A Prospective Study
TLDR
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Improved Diagnostic Performance of an Immunofluorescence-based Rapid Antigen Detection Test for Group A Streptococci in Children With Pharyngitis
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The immunofluorescence-based assay demonstrated improved diagnostic performances over the standard immunochromatographic RADT, Similarly specific for GAS detection, it demonstrates significantly higher sensitivity in children with McIsaac scores 2 or more, making it an appropriate tool in pediatric emergency settings. Expand
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