Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.

@article{Reynolds2009RapidDD,
  title={Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.},
  author={Mindy F Reynolds and Elizabeth C Peterson-Roth and Ivan A. Bespalov and Tatiana Johnston and Volkan M Gurel and Haley L Menard and Anatoly Zhitkovich},
  journal={Cancer research},
  year={2009},
  volume={69 3},
  pages={1071-9}
}
Mismatch repair (MMR) strongly enhances cyto- and genotoxicity of several chemotherapeutic agents and environmental carcinogens. DNA double-strand breaks (DSB) formed after two replication cycles play a major role in MMR-dependent cell death by DNA alkylating drugs. Here, we examined DNA damage detection and the mechanisms of the unusually rapid induction of DSB by MMR proteins in response to carcinogenic chromium(VI). We found that MSH2-MSH6 (MutSalpha) dimer effectively bound DNA probes… CONTINUE READING
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Occupational Safety and Health Administration (OSHA), Department of Labor. Occupational exposure to hexavalent chromium

  • Cancer Res Mindy F. Reynolds, Elizabeth C. Peterson-Roth, Ivan A. Bespalov
  • Final rule. Fed Regist
  • 2009
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