Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex

  title={Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex},
  author={Benjamin J Nichols and Anne K. Kenworthy and Roman S. Polishchuk and Robert Lodge and Theresa H. Roberts and Koret Hirschberg and Robert D. Phair and Jennifer Lippincott-Schwartz},
  journal={The Journal of Cell Biology},
  pages={529 - 542}
The endocytic itineraries of lipid raft markers, such as glycosyl phosphatidylinositol (GPI)-anchored proteins and glycosphingolipids, are incompletely understood. Here we show that different GPI-anchored proteins have different intracellular distributions; some (such as the folate receptor) accumulate in transferrin-containing compartments, others (such as CD59 and GPI-linked green fluorescent protein [GFP]) accumulate in the Golgi apparatus. Selective photobleaching shows that the Golgi pool… CONTINUE READING
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Direct pathway from early/recycling endosomes and the Golgi apparatus revealed through the study of Shiga toxin B subunit

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