Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens1,2

  title={Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens1,2},
  author={J. Kim and Whasun Lim and Fuller W. Bazer and Gwonhwa Song},
  journal={Journal of Animal Science},
  pages={5100 - 5104}
Abstract The aim of this study was to determine the regulatory mechanisms of molting and recrudescence via studying the micro-RNA (miRNA) expression in the oviduct of laying hens. We performed a cDNA microarray analysis in the magnum tissue from the oviduct to identify the whole miRNA profiles through the molting and recrudescence periods. A total of 35 laying hens (47-wk-old) were divided into 7 groups (0 d: a control group; 6 and 12 d: 2 molting-period groups fed on a high-zinc diet; and 20… 
2 Citations

Figures from this paper

The Role of miRNA in Differentiation, Cell Proliferation, and Pathogenesis of Poultry Diseases

  • A. Yakovlev
  • Biology
    Russian Journal of Developmental Biology
  • 2019
The findings confirm the key role of miRNA in controlling the metabolic switch that occurs between the embryo development and the chick hatching and a new understanding into the functions of miRNAs during chicken gonads’ rapid development is being formed.

Reproduction in the female



Recrudescence Mechanisms and Gene Expression Profile of the Reproductive Tracts from Chickens during the Molting Period

Global gene expression profiles following oviductal tissue regression and regeneration in laying hens in which molting was induced by feeding high levels of zinc in the diet suggest that miRNA-mediated regulation of key genes likely contributes to remodeling of the avian reproductive tract by controlling expression of those genes post-transcriptionally.

Characterization and miRNA-mediated posttranscriptional regulation of vitelline membrane outer layer protein I in the adult chicken oviduct

The results suggest that VMO-1 is an estrogen-induced gene that is posttranscriptionally regulated by microRNAs (miRNAs) that may contribute to an understanding of egg component production during chicken oviduct development.

Involvement of apoptosis and lysosomal hydrolase activity in the oviducal regression during induced molting in chickens: a cytochemical study for end labeling of fragmented DNA and acid phosphatase.

Induced molting improves egg producing functions in hens and apoptosis is induced in the earlier stage of oviducal regression and autolysis occurs thereafter eventually, the glandular cells disappear.

MicroRNA in the ovary and female reproductive tract.

This review discusses all the work regarding miRNA regulation within the mammalian female reproductive system published to date and indicates the presence of large numbers of miRNA within reproductive tissues and cells.

The physiology of induced molting.

The process of molting, and the subsequent recovery from the molt, may be viewed as a complex physiological constellation, induced by environmental and nutritional cues, involving endocrine systems, reproductive tissue structure and function, lymphoid structure, and immune function.

Tissue-protective effects of estrogen involve regulation of caspase gene expression.

The results demonstrate that estrogen has the potential to oppose apoptosis by regulating caspase activity through both transcriptional and posttranscriptional mechanisms in reproductive tissues.

Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation

It is proposed that translation regulation by microRNPs oscillates between repression and activation during the cell cycle, and two well-studied microRNAs—Let-7 and the synthetic microRNA miRcxcr4—likewise induce translation up-regulation of target mRNAs on cell cycle arrest.

Physiology and behavior of the hen during induced molt.

Hens are capable of vigorous activity throughout feed deprivation periods typical of induced molts, which do not appear to take birds beyond the second phase of fasting, and alternative induced molting methods are being sought to reduce animal welfare concerns.

MicroRNAs as regulatory elements in immune system logic

The mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output are discussed, first at the level of haematic stem cells, then in innate and adaptive immune cells, and the pathological consequences of dysregulation of these mi RNAs are discussed.

Estrogen Regulation of MicroRNA Expression

Recent studies have identified miRNAs regulated by estrogens in human breast cancer cells, human endometrial stromal and myometrial smooth muscle cells, rat mammary gland, and mouse uterus, and the decline of estradiol levels in postmenopausal women has been implicated in various age-associated disorders.