Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication

@article{Goodman2005RapidCA,
  title={Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication},
  author={Russell P. Goodman and Iwan A T Schaap and Catherine Tardin and Christoph M. Erben and Richard M. Berry and Christoph F Schmidt and Andrew J. Turberfield},
  journal={Science},
  year={2005},
  volume={310},
  pages={1661 - 1665}
}
Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial… Expand
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References

SHOWING 1-10 OF 22 REFERENCES
Design and self-assembly of two-dimensional DNA crystals
TLDR
The design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules that create specific periodic patterns on the nanometre scale are reported. Expand
DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
A DNA nanostructure consisting of four four-arm junctions oriented with a square aspect ratio was designed and constructed. Programmable self-assembly of 4 × 4 tiles resulted in two distinct latticeExpand
A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron
TLDR
The design and synthesis of a 1,669-nucleotide, single-stranded DNA molecule that is readily amplified by polymerases and that, in the presence of five 40-mer synthetic oligodeoxynucleotides, folds into an octahedron structure by a simple denaturation–renaturation procedure is reported. Expand
Construction of a DNA-Truncated Octahedron
A covalently closed molecular complex whose double-helical edges have the connectivity of a truncated octahedron has been assembled from DNA on a solid support. This three-connected Archimedean solidExpand
Synthesis from DNA of a molecule with the connectivity of a cube
TLDR
This work reports the construction from DNA of a covalently closed cube-like molecular complex containing twelve equal-length double-helical edges arranged about eight vertices, the first construction of a closed polyhedral object from DNA. Expand
DNA in a material world
  • N. Seeman
  • Materials Science, Medicine
  • Nature
  • 2003
The specific bonding of DNA base pairs provides the chemical foundation for genetics. This powerful molecular recognition system can be used in nanotechnology to direct the assembly of highlyExpand
Localized single-stranded bubble mechanism for cyclization of short double helix DNA.
TLDR
It is argued that for short molecules, the formation of a few base pairs of single-stranded DNA can provide a "flexible hinge" that facilitates loop formation. Expand
DNA twisting flexibility and the formation of sharply looped protein-DNA complexes.
  • T. Cloutier, J. Widom
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
TLDR
It is shown that the inherent twistability of 89- to 105-bp DNA circles exceeds theoretical expectation by up to 400-fold, which invalidate the use of classic theories of flexibility for understanding sharp DNA looping but support predictions of two recent theories. Expand
Overstretching B-DNA: The Elastic Response of Individual Double-Stranded and Single-Stranded DNA Molecules
TLDR
DsDNA molecules in aqueous buffer undergo a highly cooperative transition into a stable form with 5.8 angstroms rise per base pair, that is, 70% longer than B-form dsDNA, which may play a significant role in the energetics of DNA recombination. Expand
Paranemic cohesion of topologically-closed DNA molecules.
TLDR
The efficacy of PX cohesion is demonstrated by showing that it can result in the 1:1 binding of two triangle motifs, each containing nearly 500 nucleotides, demonstrating an alternative to binding nucleic acid molecules through sticky ends. Expand
...
1
2
3
...