Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication

@article{Goodman2005RapidCA,
  title={Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication},
  author={Russell P. Goodman and Iwan A T Schaap and Catherine Tardin and Christoph M. Erben and Richard M. Berry and Christoph F. Schmidt and Andrew J. Turberfield},
  journal={Science},
  year={2005},
  volume={310},
  pages={1661 - 1665}
}
Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial… 

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