Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication

@article{Goodman2005RapidCA,
  title={Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication},
  author={R. P. Goodman and I. Schaap and C. Tardin and C. M. Erben and R. Berry and C. F. Schmidt and A. Turberfield},
  journal={Science},
  year={2005},
  volume={310},
  pages={1661 - 1665}
}
  • R. P. Goodman, I. Schaap, +4 authors A. Turberfield
  • Published 2005
  • Medicine, Chemistry
  • Science
  • Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial… CONTINUE READING

    Topics from this paper.

    Rational design of DNA nanoarchitectures.
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    Nanofabrication by DNA self-assembly
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    DNA polyhedra with T-linkage.
    21
    Nanomaterials based on DNA.
    761
    DNA self-assembly for nanomedicine.
    85

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