Rapid Cellular Turnover in Adipose Tissue

@inproceedings{Rigamonti2011RapidCT,
  title={Rapid Cellular Turnover in Adipose Tissue},
  author={Alessandra Rigamonti and Kristen Brennand and Frank W K Lau and Chad A. Cowan},
  booktitle={PloS one},
  year={2011}
}
It was recently shown that cellular turnover occurs within the human adipocyte population. Through three independent experimental approaches--dilution of an inducible histone 2B-green fluorescent protein (H2BGFP), labeling with the cell cycle marker Ki67 and incorporation of BrdU--we characterized the degree of cellular turnover in murine adipose tissue. We observed rapid turnover of the adipocyte population, finding that 4.8% of preadipocytes are replicating at any time and that between 1-5… CONTINUE READING
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