Rapid Capture Next-Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B-Cell Precursor ALL.

@article{Stadt2016RapidCN,
  title={Rapid Capture Next-Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B-Cell Precursor ALL.},
  author={Udo zur Stadt and Gabriele M Escherich and Daniela Indenbirken and Malik Alawi and Manuela Adao and Martin A Horstmann},
  journal={Pediatric blood & cancer},
  year={2016},
  volume={63 7},
  pages={1283-6}
}
Comprehensive next-generation sequencing (NGS) applications have recently identified various recurrent kinase and cytokine receptor rearrangements in Ph-like B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) amenable to tyrosin kinase inhibitor treatment. For rapid diagnostics of kinase pathway aberrations in minimal residual disease (MRD) high-risk BCP-ALL, we developed a PCR-independent NGS custom enrichment capture panel targeting recurrent genomic alterations, which allows for the… CONTINUE READING
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