Rapid Ca2+ extrusion via the Na+/Ca2+ exchanger of the human platelet

  title={Rapid Ca2+ extrusion via the Na+/Ca2+ exchanger of the human platelet},
  author={Peter A. Valant and Philip N. Adjei and Duncan H. Haynes},
  journal={The Journal of Membrane Biology},
This communication reports the kinetics of the Na+/ Ca2+ exchanger and of the plasma membrane (PM) Ca2+ pump of the intact human platelet. The kinetic properties of these two systems were deduced by studying the rate of Ca2+ extrusion and its Na+ dependence for concentrations of cytoplasmic free Ca2+ ([Ca2+]cyt) in the 1–10-μm range. The PM Ca2+ATPase was previously characterized (Johansson, J.S. Haynes, D.H. 1988. J. Membrane Biol. 104:147–163) for [Ca2+]cyt] ≤ 1.5 μm with the fluorescent Ca2… CONTINUE READING


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