Rapid Activation of Rac GTPase in Living Cells by Force Is Independent of Src

@inproceedings{Poh2009RapidAO,
  title={Rapid Activation of Rac GTPase in Living Cells by Force Is Independent of Src},
  author={Y P Poh and Sungsoo Na and Farhan Chowdhury and Mingxing Ouyang and Yingxiao Wang and Ning Wang},
  booktitle={PloS one},
  year={2009}
}
It is well known that mechanical forces are crucial in regulating functions of every tissue and organ in a human body. However, it remains unclear how mechanical forces are transduced into biochemical activities and biological responses at the cellular and molecular level. Using the magnetic twisting cytometry technique, we applied local mechanical stresses to living human airway smooth muscle cells with a magnetic bead bound to the cell surface via transmembrane adhesion molecule integrins… CONTINUE READING