Rapid Activation of MDR 1 Gene Expression in Human Metastatic Sarcoma after in Vivo Exposure to Doxorubicin 1

@inproceedings{Abolhoda1999RapidAO,
  title={Rapid Activation of MDR 1 Gene Expression in Human Metastatic Sarcoma after in Vivo Exposure to Doxorubicin 1},
  author={Amir Abolhoda and Amy E. Wilson and Howard Ross and Peter V. Danenberg and Michael Burt and Kathleen W. Scotto},
  year={1999}
}
Overexpression of P-glycoprotein (Pgp), a multidrug transporter encoded by theMDR1 gene, is associated with chemoresistance in some human solid tumor malignancies. To date, analyses ofMDR1 levels in solid tumors have examined constitutive increases in expression at relapse. In the present study, we have evaluated the acute induction of MDR1 gene expression in a solid human tumor as a function of time in response toin vivo exposure to chemotherapy. Five patients with unresectable sarcoma… CONTINUE READING