Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation

@inproceedings{Gast2017RapidActingAH,
  title={Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation},
  author={Klaus Gast and Anja Sch{\"u}ler and Martin Wolff and Anja Thalhammer and Harald Berchtold and Norbert Nagel and Gudrun Lenherr and Gerrit Hauck and Robert Seckler},
  booktitle={Pharmaceutical Research},
  year={2017}
}
PurposeComparison of the dissociation kinetics of rapid-acting insulins lispro, aspart, glulisine and human insulin under physiologically relevant conditions.MethodsDissociation kinetics after dilution were monitored directly in terms of the average molecular mass using combined static and dynamic light scattering. Changes in tertiary structure were detected by near-UV circular dichroism.ResultsGlulisine forms compact hexamers in formulation even in the absence of Zn2+. Upon severe dilution… CONTINUE READING
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