Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor.

  title={Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor.},
  author={Ben J Gu and James S. Wiley},
  volume={107 12},
Matrix metalloproteinase-9 (MMP-9) activity is required for inflammatory response, leukocyte recruitment, and tumor invasion. There is increasing evidence suggesting that the P2X(7) receptor of mononuclear cells, which is activated by extracellular adenosine triphosphate (ATP), is involved in inflammatory responses. In this study, ATP caused a rapid release of MMP-9 and a moderate decrease in tissue inhibitor of metalloproteinase 1 (TIMP-1) release from human peripheral-blood mononuclear cells… 

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