Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

@article{Khosravi1999RapidAP,
  title={Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.},
  author={Rami Khosravi and Ruth Maya and Tanya M Gottlieb and Moshe Oren and Y. Shiloh and Dganit Shkedy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 26},
  pages={14973-7}
}
The p53 tumor-suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. This process is associated with posttranslational modifications of p53, some of which are mediated by the ATM protein kinase. However, these modifications alone may not account in full for p53 stabilization. p53's stability and activity are negatively regulated by the oncoprotein MDM2, whose gene is activated by p53. Conceivably, p53 function may be… CONTINUE READING

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