Rapid A-Amyloid Deposition and Cognitive Impairment After Cholinergic Denervation in APP / PS 1 Mice

@inproceedings{RamosRodrguez2013RapidAD,
  title={Rapid A-Amyloid Deposition and Cognitive Impairment After Cholinergic Denervation in APP / PS 1 Mice},
  author={Juan Jos{\'e} Ramos-Rodr{\'i}guez and Mar Pacheco-Herrero and Diana H. Thyssen and Maria Isabel Murillo-Carretero and Esther M. Berrocoso and Tara L Spires-Jones and Brian J. Bacskai and Monica Garcia-Alloza},
  year={2013}
}
Although extensive evidence supports the role of A-amyloid (AA) in Alzheimer disease (AD), the neurotoxic mechanisms underlying AD pathogenesis are not understood. On the other hand, neuronal loss is the pathologic feature that best correlates with cognitive impairment. We hypothesized that cholinergic neurodegeneration may lead to AA deposition and tested this by inducing selective cholinergic lesions in APPswe/PS1dE9 mice with murine p75 saporin (mu p75-SAP). Intracerebroventricular lesions… CONTINUE READING