Rapid 3-D mapping of hyperpolarized 3He spin-lattice relaxation times using variable flip angle gradient echo imaging with application to alveolar oxygen partial pressure measurement in rat lungs

The purpose of this work was to develop a rapid 3-D, variable flip angle (VFA) method for measurement of hyperpolarized 3He T 1 which accounts for the effects of radiofrequency (RF) pulses without the need for additional flip angle information. The 3-D, VFA method was validated in vitro over a range of oxygen partial pressures ranging from 0.04 to 0.52 atm… CONTINUE READING