Rapid, transient synaptic plasticity in addiction

@article{Gipson2014RapidTS,
  title={Rapid, transient synaptic plasticity in addiction},
  author={Cassandra D. Gipson and Yonatan M Kupchik and Peter W. Kalivas},
  journal={Neuropharmacology},
  year={2014},
  volume={76},
  pages={276-286}
}

• Cassandra D. Gipson, Yonatan M Kupchik, Peter W. Kalivas
• Published 2014 in Neuropharmacology
• DOI:10.1016/j.neuropharm.2013.04.032

Chronic use of addictive drugs produces enduring neuroadaptations in the corticostriatal glutamatergic brain circuitry. The nucleus accumbens (NAc), which integrates cortical information and regulates goal-directed behavior, undergoes long-term morphological and electrophysiological changes that may underlie the increased susceptibility for relapse in drug-experienced individuals even after long periods of withdrawal. Additionally, it has recently been shown that exposure to cues associated… CONTINUE READING

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