Rapid, transient synaptic plasticity in addiction

@article{Gipson2014RapidTS,
  title={Rapid, transient synaptic plasticity in addiction},
  author={Cassandra D. Gipson and Yonatan M Kupchik and Peter W. Kalivas},
  journal={Neuropharmacology},
  year={2014},
  volume={76},
  pages={276-286}
}
Chronic use of addictive drugs produces enduring neuroadaptations in the corticostriatal glutamatergic brain circuitry. The nucleus accumbens (NAc), which integrates cortical information and regulates goal-directed behavior, undergoes long-term morphological and electrophysiological changes that may underlie the increased susceptibility for relapse in drug-experienced individuals even after long periods of withdrawal. Additionally, it has recently been shown that exposure to cues associated… CONTINUE READING
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