Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.

  title={Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.},
  author={Michael J. Krashes and Shuichi Koda and Chianping Ye and Sarah C. Rogan and Andrew Charles Adams and Daniel S Cusher and Eleftheria Maratos-Flier and Bryan L. Roth and Bradford B. Lowell},
  journal={The Journal of clinical investigation},
  volume={121 4},
Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete. Using designer receptors exclusively activated by designer drugs (DREADD) technology to provide specific and reversible regulation of neuronal activity in mice, we have demonstrated that acute activation of AgRP neurons rapidly and dramatically induces… CONTINUE READING
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