Rapid, non-invasive imaging of alphaviral brain infection: reducing animal numbers and morbidity to identify efficacy of potential vaccines and antivirals.

@article{Patterson2011RapidNI,
  title={Rapid, non-invasive imaging of alphaviral brain infection: reducing animal numbers and morbidity to identify efficacy of potential vaccines and antivirals.},
  author={Michael V. Patterson and Allison L. Poussard and K. H. Taylor and Alexey V. Seregin and Jeanon N. Smith and Bi-Hung Peng and Aida G. Walker and Jenna J Linde and Jennifer K. Smith and Milagros Salazar and Slobodan Paessler},
  journal={Vaccine},
  year={2011},
  volume={29 50},
  pages={9345-51}
}
Rapid and accurate identification of disease progression are key factors in testing novel vaccines and antivirals against encephalitic alphaviruses. Typical efficacy studies utilize a large number of animals and severe morbidity or mortality as an endpoint. New technologies provide a means to reduce and refine the animal use as proposed in Hume's 3Rs (replacement, reduction, refinement) described by Russel and Burch. In vivo imaging systems (IVIS) and bioluminescent enzyme technologies… CONTINUE READING
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