Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy.

  title={Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy.},
  author={Minbiao Ji and Daniel A. Orringer and Christian W. Freudiger and Shakti H. Ramkissoon and Xiaohui Liu and Darryl Lau and Alexandra J. Golby and Isaiah Norton and Marika Hayashi and Nathalie Y. R. Agar and G S Young and Cathie Spino and Sandro Santagata and Sandra Ines Camelo-Piragua and Keith L Ligon and Oren Sagher and Xiaoliang Sunney Xie},
  journal={Science translational medicine},
  volume={5 201},
Surgery is an essential component in the treatment of brain tumors. However, delineating tumor from normal brain remains a major challenge. We describe the use of stimulated Raman scattering (SRS) microscopy for differentiating healthy human and mouse brain tissue from tumor-infiltrated brain based on histoarchitectural and biochemical differences. Unlike traditional histopathology, SRS is a label-free technique that can be rapidly performed in situ. SRS microscopy was able to differentiate… CONTINUE READING
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