Rapid, accurate, computational discovery of Rho-independent transcription terminators illuminates their relationship to DNA uptake

@article{Kingsford2006RapidAC,
  title={Rapid, accurate, computational discovery of Rho-independent transcription terminators illuminates their relationship to DNA uptake},
  author={Carleton L. Kingsford and Kunmi Ayanbule and Steven L Salzberg},
  journal={Genome Biology},
  year={2006},
  volume={8},
  pages={R22 - R22}
}
In many prokaryotes, transcription of DNA to RNA is terminated by a thymine-rich stretch of DNA following a hairpin loop. Detecting such Rho-independent transcription terminators can shed light on the organization of bacterial genomes and can improve genome annotation. Previous computational methods to predict Rho-independent terminators have been slow or limited in the organisms they consider. We describe TransTermHP, a new computational method to rapidly and accurately detect Rho-independent… CONTINUE READING
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