Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16

@inproceedings{Launay2011RaphemediatedSC,
  title={Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16},
  author={J M Launay and Sophie Mouillet-Richard and Anne Baudry and M Pietri and Odile Kellermann},
  booktitle={Translational Psychiatry},
  year={2011}
}
Serotonin reuptake inhibitor (SRI) antidepressants such as fluoxetine (Prozac), promote hippocampal neurogenesis. They also increase the levels of the bcl-2 protein, whose overexpression in transgenic mice enhances adult hippocampal neurogenesis. However, the mechanisms underlying SRI-mediated neurogenesis are unclear. Recently, we identified the microRNA miR-16 as an important effector of SRI antidepressant action in serotonergic raphe and noradrenergic locus coeruleus (LC). We show here that… CONTINUE READING