Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish

@article{Siebel2015RapamycinSP,
  title={Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish},
  author={A. Siebel and F. P. Menezes and Isabel C Schaefer and B. Petersen and C. Bonan},
  journal={Pharmacology Biochemistry and Behavior},
  year={2015},
  volume={139},
  pages={163-168}
}
The mTORC1 complex integrates different inputs from intracellular and extracellular signals to control various cellular processes. Therefore, any disruption in the mTORC1 pathway could promote different neurological disorders. mTORC1 overactivation has been verified in different genetic and acquired epilepsy animal models. Therefore, inhibitors of this complex could have both antiepileptogenic and antiseizure effects. In our study, we investigated the effects of rapamycin pretreatment on… Expand
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