Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

  title={Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.},
  author={Manuela Battaglia and Angela Stabilini and Maria Grazia Roncarolo},
  volume={105 12},
Rapamycin is an immunosuppressive compound that is currently used to prevent acute graft rejection in humans. In addition, rapamycin has been shown to allow operational tolerance in murine models. However, a direct effect of rapamycin on T regulatory (Tr) cells, which play a key role in induction and maintenance of peripheral tolerance, has not been demonstrated so far. Here, we provide new evidence that rapamycin selectively expands the murine naturally occurring CD4(+)CD25(+)FoxP3(+) Tr cells… CONTINUE READING
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