Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation.

@article{Sun2008RapamycinRT,
  title={Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation.},
  author={Qiaoling Sun and Yuanyuan Zheng and Qiuyan Liu and Xuetao Cao},
  journal={International immunopharmacology},
  year={2008},
  volume={8 13-14},
  pages={1854-8}
}
Toll-like receptor 4 (TLR4) signaling in tumor cells can promote tumor escape and tumor progression, for which TLR4-triggered resistance of tumor cells to apoptosis has been proposed as one of the mechanisms. Rapamycin is an immunosuppressant agent widely used for treatment of transplantation rejection and autoimmune diseases, and recently used for cancer… CONTINUE READING