Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

Abstract

OBJECTIVE Tuberous sclerosis complex (TSC) represents one of the most common genetic causes of epilepsy. TSC gene inactivation leads to hyperactivation of the mammalian target of rapamycin signaling pathway, raising the intriguing possibility that mammalian target of rapamycin inhibitors might be effective in preventing or treating epilepsy in patients with… (More)
DOI: 10.1002/ana.21331

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Cite this paper

@article{Zeng2008RapamycinPE, title={Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.}, author={Ling-hui Zeng and Lin Xu and David H. Gutmann and Michael Kien Yee Wong}, journal={Annals of neurology}, year={2008}, volume={63 4}, pages={444-53} }