Rapamycin prevents early steps of the development of diabetic nephropathy in rats.

@article{Yang2007RapamycinPE,
  title={Rapamycin prevents early steps of the development of diabetic nephropathy in rats.},
  author={Yi Yang and Jingjing Wang and Ling Qin and Zhangfei Shou and J. R. Zhao and Huiping Wang and Yin Chen and Jianghua Chen},
  journal={American journal of nephrology},
  year={2007},
  volume={27 5},
  pages={495-502}
}
BACKGROUND/AIMS Recent studies suggested the involvement of the Akt/mammalian target of rapamycin (mTOR) pathway in the pathogenesis of diabetic nephropathy. The effect of mTOR blockade by rapamycin in diabetic nephropathy was investigated, but in vivo study of rapamycin treatment in the course of early diabetes is still insufficient. This study was designed to determine the therapeutic effects of rapamycin on diabetic nephropathy at an early stage. METHODS Diabetes was induced in Sprague… CONTINUE READING