Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells.

@article{Valmori2006RapamycinmediatedEO,
  title={Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells.},
  author={Danila Valmori and Valeria Tosello and Naira E. Souleimanian and Emmanuelle Godefroy and Luigi Scotto and Yu Wang and Maha Ayyoub},
  journal={Journal of immunology},
  year={2006},
  volume={177 2},
  pages={944-9}
}
Rapamycin is an immunosuppressive drug currently used in different clinical settings. Although the capacity of rapamycin to inhibit the mammalian target of rapamycin serine/threonine protein kinase and therefore T cell cycle progression is well known, its effects are complex and not completely understood. It has been reported recently that TCR-mediated stimulation of murine CD4+ T cells in the presence of rapamycin results in increased proportions of CD4+ T cells with suppressive functions… CONTINUE READING