Rapamycin-mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae.

@article{Zinzalla2007RapamycinmediatedGA,
  title={Rapamycin-mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae.},
  author={Vittoria Zinzalla and Michele Graziola and Andrea Mastriani and Marco Vanoni and Lilia Alberghina},
  journal={Molecular microbiology},
  year={2007},
  volume={63 5},
  pages={1482-94}
}
The rapamycin-sensitive (TOR) signalling pathway in Saccharomyces cerevisiae controls growth and cell proliferation in response to nutrient availability. Rapamycin treatment causes cells to arrest growth in G1 phase. The mechanism by which the inhibition of the TOR pathway regulates cell cycle progression is not completely understood. Here we show that rapamycin causes G1 arrest by a dual mechanism that comprises downregulation of the G1-cyclins Cln1-3 and upregulation of the Cdk inhibitor… CONTINUE READING
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