Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver.

  title={Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver.},
  author={Yuhong Jiang and Lisa M. Ballou and Richard Z. Lin},
  journal={The Journal of biological chemistry},
  volume={276 14},
In cultured cells, growth factor-induced phosphorylation of two translation modulators, p70 S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), is blocked by nanomolar concentrations of the immunosuppressant rapamycin. Rapamycin also attenuates liver regeneration after partial hepatectomy, but it is not known if this growth-suppressive effect is due to dephosphorylation of p70 S6 kinase and/or 4E-BP1. We found that partial hepatectomy induced a transient increase in liver… CONTINUE READING


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