Rapamycin inhibits the growth of glioblastoma.

  title={Rapamycin inhibits the growth of glioblastoma.},
  author={Antonietta Arcella and Francesca Biagioni and Maria Antonietta Oliva and Domenico Bucci and Alessandro Frati and Vincenzo Esposito and Giampaolo Cantore and Felice Giangaspero and Francesco Fornai},
  journal={Brain research},
The molecular target of rapamycin (mTOR) is up-regulated in glioblastoma (GBM) and this is associated with the rate of cell growth, stem cell proliferation and disease relapse. Rapamycin is a powerful mTOR inhibitor and strong autophagy inducer. Previous studies analyzed the effects of rapamycin in GBM cell lines. However, to our knowledge, no experiment was carried out to evaluate the effects of rapamycin neither in primary cells derived from GBM patients nor in vivo in brain GBM xenograft… CONTINUE READING
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