Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol.

@article{Kline2007RapamycinIT,
  title={Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol.},
  author={William O. Kline and Frank J Panaro and Hayung Yang and Sue C. Bodine},
  journal={Journal of applied physiology},
  year={2007},
  volume={102 2},
  pages={
          740-7
        }
}
Clenbuterol and other beta2-adrenergic agonists are effective at inducing muscle growth and attenuating muscle atrophy through unknown mechanisms. This study tested the hypothesis that clenbuterol-induced growth and muscle sparing is mediated through the activation of Akt and mammalian target of rapamycin (mTOR) signaling pathways. Clenbuterol was administered to normal weight-bearing adult rats to examine the growth-inducing effects and to adult rats undergoing muscle atrophy as the result of… Expand
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