Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin.

@article{Visner2003RapamycinIH,
  title={Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin.},
  author={Gary A. Visner and Fuhua Lu and Hailan Zhou and Jun Liu and Kristy Kazemfar and Anupam Agarwal},
  journal={Circulation},
  year={2003},
  volume={107 6},
  pages={
          911-6
        }
}
BACKGROUND Rapamycin is an immunosuppressive agent with antiproliferative properties against not only lymphocytes but also vascular endothelial and smooth muscle cells, and it reduces the fibroproliferative response to vascular injury. Heme oxygenase-1 (HO-1) has also been shown to have graft protective effects and to inhibit vascular remodeling. In this study, we evaluated whether there is an interaction between rapamycin and HO-1. METHODS AND RESULTS In human pulmonary artery endothelial or… CONTINUE READING

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