Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages.

@article{Woltman2001RapamycinIA,
  title={Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages.},
  author={Andrea M. Woltman and Johan W. de Fijter and Sylvia W A Kamerling and Sandra W van der Kooij and Leendert C. Paul and Mohamed R. Daha and Cees van Kooten},
  journal={Blood},
  year={2001},
  volume={98 1},
  pages={174-80}
}
Rapamycin (Rapa), a recently introduced immunosuppressive drug, seems to be effective in preventing acute allograft rejection. Although its antiproliferative effect on T lymphocytes has been investigated extensively, its effect on the initiators of the immune response, the dendritic cells (DCs), is not known. Therefore, the effect of Rapa on monocyte- (mo-DCs) and CD34(+)-derived DCs in vitro but also on other myeloid cell types, including monocytes and macrophages, was examined. The present… CONTINUE READING
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The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells

  • AM Woltman, JW Fijter, SWA Kamerling, LC Paul, MR Daha, C. Van Kooten
  • Eur J Immunol
  • 2000

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