Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase

@article{Xu2015RapamycinIC,
  title={Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase},
  author={Xuefeng Xu and Huaping Dai and Jing Geng and Xuan Wan and Xiaoxi Huang and Fei Li and Dianhua Jiang and Chen Wang},
  journal={Laboratory Investigation},
  year={2015},
  volume={95},
  pages={846-859}
}
Excessive production of connective tissue growth factor (CTGF, CCN2) and increased motor ability of the activated fibroblast phenotype contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, molecules and signal pathways regulating CCN2 expression and migration of lung fibroblasts are still elusive. We hypothesize that rapamycin, via binding and blocking mammalian target of rapamycin (mTOR) complex (mTORC), affects CCN2 expression and migration of lung fibroblasts in… CONTINUE READING
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