Rapamycin enhances platelet aggregation induced by adenosine diphosphate in vitro.

  title={Rapamycin enhances platelet aggregation induced by adenosine diphosphate in vitro.},
  author={Qi Wu and Kai-sen Huang and Mao Chen and De-jia Huang},
  volume={20 6},
Studies have demonstrated the important role of platelets in the formation of stent thrombosis associated with drug-eluting stents, but little is known about the effects of drugs eluted from stents on platelet function. The extent of platelet aggregation in platelet-rich plasma induced by adenosine diphosphate (ADP) was measured at various doses of rapamycin, and the ability of aspirin to inhibit platelet aggregation was determined at the same concentrations of rapamycin. Compared with lower… CONTINUE READING


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Tailoring clopidogrel loading on the basis of responsiveness testing reduces stent thrombosis

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