Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27 Kip1 -independent pathway.

@article{Castro2004RapamycinAA,
  title={Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27 Kip1 -independent pathway.},
  author={Claudia Castro and Josep Mar{\'i}a Campistol and David de Sancho and Francisco S{\'a}nchez-Madrid and Elena Casals and Vicente Andr{\'e}s},
  journal={Atherosclerosis},
  year={2004},
  volume={172 1},
  pages={31-8}
}
Activation of immune cells and dysregulated growth and motility of vascular smooth muscle cells contribute to neointimal lesion development during the pathogenesis of vascular obstructive disease. Inhibition of these processes by the immunosuppressant rapamycin is associated with reduced neointimal thickening in the setting of balloon angioplasty and chronic graft vessel disease (CGVD). In this study, we show that rapamycin elicits a marked reduction of aortic atherosclerosis in apolipoprotein… CONTINUE READING

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